In a world-first medical milestone, Japanese scientists have officially begun human trials for a drug that can regrow natural teeth.
The groundbreaking treatment, developed by a team at Kyoto University Hospital led by Dr. Katsu Takahashi, targets a protein called USAG-1, which normally suppresses tooth development. By blocking this protein, the drug reactivates the body’s dormant ability to grow new teeth — something previously thought to be impossible in adults.
In animal trials, the drug successfully caused new tooth growth within weeks, restoring full dental function. Now, the first phase of human testing focuses on safety and dosage, beginning with patients suffering from congenital tooth loss. If successful, future phases will extend to adults who’ve lost teeth due to injury or decay.
This revolutionary treatment could eliminate the need for dentures and implants, redefining dentistry as we know it. Japan’s progress marks a historic leap forward — one that could allow people to naturally regrow their own teeth within the next decade.
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